O'Connor, a senior guard from Alpharetta, Ga., keyed the Paladins' solid 3-point shooting effort by connecting on 4-of-6 shots from behind the arc, and in all converted 7-of-14 shots from the field in 28 minutes of action to pace the Paladin attack.
Kendra Berry and Martha Robinson added 13 points apiece, and Katilin Murphy rounded out the double figure scoring display with 12 points. Berry led all rebounders with nine caroms, and Murphy racked up nine assists for the Paladins.
Furman drained 6-of-12 3-point shots in the contest and shot 44.6 percent from the field (25-of-56).
Bridget Ansbro led Limestone with 16 points, and Tia Williams contributed 11 and Ashley Robinson 10 points for the Saints.
Furman quickly erased an early deficit with a Murphy 3-pointer that put the Paladins ahead, 6-4, a little over two minutes into the game.
The advantage grew to as many as 18 points in the first half, first on an O'Connor trey at the 7:01 mark that made it 29-11, and later on two Berry free throws with 28 seconds that pushed Furman's advantage to 40-22.
The Paladins maintained a comfortable double digit lead in the second half on the strength of 50.0 percent shooting from the field (12-of-24).
Furman, which limited Limestone to just 9-of-29 shooting (31.0 percent) over the game's final 20 minutes, also posted a 43-30 rebounding advantage the contest.
The Paladins tip off the 2010-11 season on the road this Friday at Indiana State. Game time is set for 7:00 p.m. Live stats will be available through www.furmanpaladins.com